遗传学（第10版）（双语版） - 中国高校教材图书网
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本书为美国经典的遗传学教材《遗传学》（第10版）的双语版改编教材。本书根据中国遗传学教学计划及各遗传学教学实际，对原书进行改编，删除与分子生物学课程重叠的内容，保留经典遗传学（1—8）章和现代遗传学进展（17—19章），补充部分遗传学背景知识，如孟德尔的经典遗传学文献、真菌的遗传分析、细菌的遗传作图、病毒的遗传作图等。全书对重点章节配有中文翻译，并补充了中英双语的高频遗传学专业词汇。此外，本书还将配备网络双语试题库供教师和学生学习使用。
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【美】威廉· S. 克卢格（William S. Klug）等 ---------------------------- 威廉· S. 克卢格（William S. Klug），新泽西学院（前特兰顿州立学院）的生物学教授。自1974年起连续17年担任生物系主任。获得2004年Sigma-Pi国际杰出教授奖，同年，被提名为新泽西州研究与发展委员会的年度教育工作者。宣劲松 ---------------------------- 宣劲松，1999年获北京师范大学生物化学学士，2002年获北京师范大学生物化学与分子生物学硕士，2005年获中科院遗传发育所遗传学博士。现为北京科技大学副教授。
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1 Introduction to Genetics1 绪论1.1 Genetics Has an Interesting Early History1.1 有趣的遗传学早期历史1.2 Genetics Progressed from Mendel to DNA in Less Than a Century1.2 从孟德尔到DNA ——遗传学在一个世纪内的飞速进展1.3 Discovery of the Double Helix Launched the Era of Molecular Genetics1.3 DNA 双螺旋结构的发现开启了分子遗传学新纪元1.4 Development of Recombinant DNA Technology Began the Era of DNA Cloning1.4 重组DNA 技术的发展开启了DNA 克隆时代1.5 The Impact of Biotechnology Is Continually Expanding1.5 生物技术的影响正持续扩大1.6 Genomics, Proteomics, and Bioinformatics Are New and Expanding Fields1.6 基因组学、蛋白质组学和生物信息学是日益发展的新兴领域1.7 Genetic Studies Rely on the Use of Model Organisms1.7 遗传学研究依赖于模式生物的使用1.8 Genetics Has Had a Profound Impact on Society1.8 遗传学对社会已经产生了深远影响2 Mitosis and Meiosis2 有丝分裂和减数分裂2.1 Cell Structure Is Closely Tied to Genetic Function 2.1 细胞结构与遗传功能紧密相关2.2 Chromosomes Exist in Homologous Pairs in Diploid Organisms2.2 二倍体生物中染色体以同源染色体对的形式存在2.3 Mitosis Partitions Chromosomes into Dividing Cells2.3 有丝分裂将染色体分配至分裂细胞中2.4 Meiosis Creates Haploid Gametes and Spores and Enhances Genetic Variation in Species2.4 减数分裂产生单倍体配子和孢子并增加了物种的遗传变异2.5 The Development of Gametes Varies in Spermatogenesis Compared to Oogenesis2.5 精子发生与卵子发生中的配子发育差异2.6 Meiosis Is Critical to Sexual Reproduction in All Diploid Organisms2.6 减数分裂对于所有二倍体生物的有性生殖都至关重要2.7 Electron Microscopy Has Revealed the Physical Structure of Mitotic and Meiotic Chromosomes2.7 电子显微镜揭示了有丝分裂和减数分裂过程中的染色体结构3 Mendelian Genetics3 孟德尔遗传学3.1 Mendel Used a Model Experimental Approach to Study Patterns of Inheritance3.1 孟德尔使用模型实验方法研究遗传模式3.2 The Monohybrid Cross Reveals How One Trait Is Transmitted from Generation to Generation3.2 单因子杂交揭示了单一性状世代传递的规律3.3 Mendel’s Dihybrid Cross Generated a Unique F2 Ratio3.3 孟德尔双因子杂交产生独特的F2 代比例3.4 The Trihybrid Cross Demonstrates That Mendel’s Principles Apply to Inheritance of Multiple Traits3.4 三因子杂交表明孟德尔定律适用于多性状遗传3.5 Mendel’s Work Was Rediscovered in the Early Twentieth Century3.5 孟德尔的工作在20 世纪初被重新发现3.6 Independent Assortment Leads to Extensive Genetic Variation3.6 自由组合产生广泛的遗传变异3.7 Laws of Probability Help to Explain Genetic Events3.7 概率理论有助于解释遗传学事件3.8 Chi-Square Analysis Evaluates the Influence of Chance on Genetic Data3.8 卡方分析评估偶然性对于遗传数据的影响3.9 Pedigrees Reveal Patterns of Inheritance of Human Trait3.9 系谱图揭示了人类性状的遗传模式3.10 Tay-Sachs Disease: The Molecular Basis of a Recessive Disorder in Humans3.10 泰-萨克斯病：人类隐性遗传疾病的分子基础4 Modification of Mendelian Ratios4 孟德尔比率的扩展4.1 Alleles Alter Phenotypes in Different Ways4.1 等位基因通过不同途径影响表型4.2 Geneticists Use a Variety of Symbols for Alleles4.2 遗传学家使用多种符号表示等位基因4.3 Neither Allele Is Dominant in Incomplete, or Partial, Dominance4.3 在不完全显性中没有等位基因是显性的4.4 In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident4.4 在共显性中，杂合子两种等位基因的影响十分明显4.5 Multiple Alleles of a Gene May Exist in a Population4.5 生物种群中可能存在复等位基因4.6 Lethal Alleles Represent Essential Genes 4.6 致死等位基因体现必需基因4.7 Combinations of Two Gene Pairs with Two Modes of Inheritance Modify the 9:3:3:1 Ratio4.7 两对基因通过两种遗传模式进行组合扩展了9 ∶ 3 ∶ 3 ∶ 1 比例4.8 Phenotypes Are Often Affected by More Than One Gene4.8 表型通常由一种以上的基因共同决定4.9 Complementation Analysis Can Determine if Two Mutations Causing a Similar Phenotype Are Alleles of the Same Gene4.9 互补分析可以判断引发相似表型的突变是否是同一基因的不同等位基因4.10 Expression of a Single Gene May Have Multiple Effects4.10 单基因表达可以产生多种基因效应4.11 X-Linkage Describes Genes on the X Chromosome4.11 X连锁描述位于X 染色体上的基因4.12 In Sex-Limited and Sex-Influenced Inheritance, an Individual’s Gender Influences the Phenotype4.12 在限性遗传和从性遗传中，个体的性别会影响表型4.13 Genetic Background and the Environment Affect Phenotypic Expression4.13 遗传背景与环境会影响表型表达4.14 Extranuclear Inheritance Modifies Mendelian Patterns4.14 核外遗传丰富了孟德尔遗传模式5 Sex Determination and Sex Chromosomes5 性别决定与性染色体5.1 X and Y Chromosomes Were First Linked to Sex Determination Early in the Twentieth Century5.1 20世纪初，X和Y染色体首次确定与性别决定相关5.2 The Y Chromosome Determines Maleness in Humans 5.2 Y染色体决定人类雄性发育5.3 The Ratio of Males to Females in Humans Is Not 1.05.3 人类男女性别比并非1.05.4 Dosage Compensation Prevents Excessive Expression of X-Linked Genes in Humans and Other Mammals5.4 剂量补偿避免人类及其他哺乳类动物X连锁基因的过量表达5.5 The Ratio of X Chromosomes to Sets of Autosomes Can Determine Sex5.5 X染色体数目与常染色体组数的比值可以决定性别5.6 Temperature Variation Controls Sex Determination in Reptiles5.6 温度变化控制爬行动物的性别决定6 Chromosome Mutations: Variation in Number and Arrangement6 染色体突变: 染色体数目与结构的变异6.1 Variation in Chromosome Number: Terminology and Origin6.1 染色体数目的变异：专业术语与起源6.2 Monosomy and Trisomy Result in a Variety of Phenotypic Effects6.2 单体和三体导致不同的表型效应6.3 Polyploidy, in Which More Than Two Haploid Sets of Chromosomes Are Present, Is Prevalent in Plants6.3 含两套以上单倍染色体组成的多倍体在植物界中广泛存在6.4 Variation Occurs in the Composition and Arrangement of Chromosomes6.4 染色体结构和排列顺序的变异6.5 A Deletion Is a Missing Region of a Chromosome6.5 缺失是染色体上发生丢失的一段区域6.6 A Duplication Is a Repeated Segment of a Chromosome6.6 重复是多次出现的染色体片段6.7 Inversions Rearrange the Linear Gene Sequence6.7 倒位将线性基因序列进行重排6.8 Translocations Alter the Location of Chromosomal Segments in the Genome6.8 易位改变了基因组中染色体片段的位置6.9 Fragile Sites in Human Chromosomes Are Susceptible to Breakage6.9 人类染色体的脆性位点7 Linkage and Chromosome Mapping in Eukaryotes7 真核生物的连锁与染色体作图7.1 Genes Linked on the Same Chromosome Segregate Together7.1 同一染色体上的连锁基因相伴分离7.2 Crossing Over Serves as the Basis of Determining the Distance between Genes during Mapping7.2交换是染色体作图中确定基因间距离的基础7.3 Determining the Gene Sequence during Mapping Requires the Analysis of Multiple Crossovers7.3 染色体作图中确定基因顺序需要分析多交换事件7.4 As the Distance between Two Genes Increases, Mapping Estimates Become MoreInaccurate67.4 随着基因间距离的增加，染色体作图的精确性将随之下降7.5 Chromosome Mapping Is Now Possible Using DNA Markers and Annotated Computer Databases7.5 当今，使用DNA 标记和计算机注释数据库进行染色体作图已成为可能7.6 Other Aspects of Genetic Exchange7.6 关于遗传交换的几点补充8 Genetic Analysis and Mapping in Bacteria and Bacteriophages8 细菌和噬菌体的遗传分析与染色体作图8.1 Bacteria Mutate Spontaneously and Are Easily Cultured8.1 细菌能够自发突变并易于培养8.2 Genetic Recombination Occurs in Bacteria8.2 细菌的基因重组8.3 The F Factor Is an Example of a Plasmid8.3 F 因子是一种质粒8.4 Transformation Is Another Process Leading to Genetic Recombination in Bacteria8.4 转化是细菌进行遗传重组的另一种方式8.5 Bacteriophages Are Bacterial Viruses8.5 噬菌体是细菌病毒8.6 Transduction Is Virus-Mediated Bacterial DNA Transfer8.6 转导是由病毒介导的细菌DNA 转移9 Epigenetics9 表观遗传学9.1 Molecular Alterations to the Genome Create an Epigenome9.1 基因组的分子变化产生了表观基因组9.2 Epigenetics and Monoallelic Gene Expression9.2 表观遗传学与单等位基因表达9.3 Epigenetics and Cancer9.3 表观遗传学与癌症9.4 Epigenetic Traits Are Heritable9.4 表观遗传性状具有可遗传性9.5 Epigenome Projects and Databases 9.5 表观基因组计划与数据库10 Genetic Testing10 遗传检测10.1 Testing for Prognostic or Diagnostic Purposes10.1 预后检测和诊断检测10.2 Prenatal Genetic Testing to Screen for Conditions10.2 用于遗传筛查的产前遗传检测10.3 Genetic Testing Using Allele-Specific Oligonucleotides10.3 利用等位基因特异的寡核苷酸进行遗传检测10.4 Microarrays for Genetic Testing10.4 用于遗传诊断的微阵列10.5 Genetic Analysis of Individual Genomes by DNA Sequencing10.5 运用DNA 测序进行个体基因组遗传分析10.6 Genome-Wide Association Studies Identify Genome Variations That Contribute to Disease10.6 全基因组关联分析鉴定导致疾病的基因组变异10.7 Genetic Testing and Ethical, Social, and Legal Questions10.7 遗传检测与伦理、社会和法律问题11 Gene Therapy11 基因治疗11.1 What Genetic Conditions Are Candidates for Treatment by Gene Therapy?11.1 哪些遗传疾病有望使用基因治疗？11.2 How Are Therapeutic Genes Delivered?11.2 如何传送治疗基因？11.3 The First Successful Gene Therapy Trial11.3 首个基因治疗成功案例11.4 Gene Therapy Setbacks11.4 基因治疗的逆境11.5 Recent Successful Trials by Conventional Gene Therapy Approaches 11.5 传统基因治疗技术的近期成功尝试11.6 Genome-Editing Approaches to Gene Therapy11.6 基因治疗中的基因编辑法11.7 Future Challenges and Ethical Issues11.7 未来的挑战及伦理问题12 Advances in Neurogenetics: The Study of Huntington Disease12 神经遗传学进展：亨廷顿病的研究12.1 The Search for the Huntington Gene12.1 寻找亨廷顿病基因12.2 The HTT Gene and Its Protein Product12.2 HTT 基因与其蛋白质产物12.3 Molecular and Cellular Alterations in Huntington Disease12.3 亨廷顿病的分子变化和细胞变化12.4 Transgenic Animal Models of Huntington Disease12.4 亨廷顿病的转基因动物模型12.5 Cellular and Molecular Approaches to Therapy12.5 治疗的细胞生物学和分子生物学方法13 DNA Forensics13 DNA 法医学13.1 DNA Profiling Methods13.1 DNA 分析方法13.2 Interpreting DNA Profiles13.2 DNA 图谱诠释13.3 Technical and Ethical Issues Surrounding DNA Profiling13.3 围绕DNA 分析的技术与伦理问题14 Genetically Modified Foods14 转基因食品14.1 What Are GM Foods?14.1 什么是转基因食品？14.2 Methods Used to Create GM Plants14.2 构建GM 植物的方法14.3 GM Foods Controversies14.3 GM 食品之争14.4 The Future of GM Foods14.4 GM 食品的未来15 Genomics and Precision Medicine15 基因组学与精准医疗15.1 Pharmacogenomics15.1 药物基因组学15.2 Precision Oncology15.2 精准肿瘤学15.3 Precision Medicine and Disease Diagnostics15.3 精准医疗与疾病诊断15.4 Technical, Social, and Ethical Challenges15.4 技术、社会和伦理的挑战
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